• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

SIRT7 inhibitor 97491

CAS No. 1807758-81-1

SIRT7 inhibitor 97491 ( —— )

产品货号. M28213 CAS No. 1807758-81-1

SIRT7 抑制剂 97491 是一种 HDAC 抑制剂,对 SIRT7 具有高特异性 (IC50 = 325 nM)。 SIRT7 抑制剂 97491 通过 caspase 途径促进细胞凋亡。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2001 有现货
10MG ¥3013 有现货
25MG ¥5095 有现货
50MG ¥7258 有现货
100MG ¥9882 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    SIRT7 inhibitor 97491
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    SIRT7 抑制剂 97491 是一种 HDAC 抑制剂,对 SIRT7 具有高特异性 (IC50 = 325 nM)。 SIRT7 抑制剂 97491 通过 caspase 途径促进细胞凋亡。
  • 产品描述
    SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.(In Vitro):SIRT7 inhibitor 97491 decreased SIRT7 activity in a dose-dependent manner. SIRT7 inhibitor 97491 induced expression of p53 and its acetylation by inhibited SIRT7. SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.(In Vivo):In xenograft mice, SIRT7 inhibitor 97491 (2 mg/kg; i.p) inhibited tumor growth. SIRT7 inhibitor 97491 upregulated apoptotic effects through the caspase related proteins and inhibited cancer growth in vivo.
  • 体外实验
    Cell Proliferation Assay Cell Line:Human uterine sarcoma MES-SA cells Concentration:1, 5, 10 μM Incubation Time:72 hours Result:Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay Cell Line:Human embryonic kidney cell line HEK293 cells Concentration:1, 5, 10 μM Incubation Time:24 hours Result:HEK293 cells were almost unaffected.
  • 体内实验
    Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells Dosage:2 mg/kg Administration:Intraperitoneally injected; for 3 weeks, except on weekends. Result:Inhibited cancer growth in vivo.
  • 同义词
    ——
  • 通路
    Chromatin/Epigenetic
  • 靶点
    Sirtuin
  • 受体
    β-Lactamase
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1807758-81-1
  • 分子量
    285.73
  • 分子式
    C15H12ClN3O
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 500 mg/mL (1749.90 mM)
  • SMILES
    Nc1cccc(Nc2ncc(-c(cc3)ccc3Cl)o2)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Papp-Wallace KM, et al. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086.
产品手册
关联产品
  • Selisistat S-enantio...

    EX-527 S-对映体是 EX-527 的 S-对映体,对 SIRT1 的 IC50 为 123 nM。

  • MC2184

    MC2184 是人重组 SIRT1 的抑制剂。

  • AEM2

    SIRT2抑制剂AEM2 (AEM2)是一种选择性SIRT2抑制剂,IC50为3.8 uM。