
SIRT7 inhibitor 97491
CAS No. 1807758-81-1
SIRT7 inhibitor 97491 ( —— )
产品货号. M28213 CAS No. 1807758-81-1
SIRT7 抑制剂 97491 是一种 HDAC 抑制剂,对 SIRT7 具有高特异性 (IC50 = 325 nM)。 SIRT7 抑制剂 97491 通过 caspase 途径促进细胞凋亡。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2001 | 有现货 |
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10MG | ¥3013 | 有现货 |
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25MG | ¥5095 | 有现货 |
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50MG | ¥7258 | 有现货 |
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100MG | ¥9882 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SIRT7 inhibitor 97491
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述SIRT7 抑制剂 97491 是一种 HDAC 抑制剂,对 SIRT7 具有高特异性 (IC50 = 325 nM)。 SIRT7 抑制剂 97491 通过 caspase 途径促进细胞凋亡。
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产品描述SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.(In Vitro):SIRT7 inhibitor 97491 decreased SIRT7 activity in a dose-dependent manner. SIRT7 inhibitor 97491 induced expression of p53 and its acetylation by inhibited SIRT7. SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.(In Vivo):In xenograft mice, SIRT7 inhibitor 97491 (2 mg/kg; i.p) inhibited tumor growth. SIRT7 inhibitor 97491 upregulated apoptotic effects through the caspase related proteins and inhibited cancer growth in vivo.
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体外实验Cell Proliferation Assay Cell Line:Human uterine sarcoma MES-SA cells Concentration:1, 5, 10 μM Incubation Time:72 hours Result:Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay Cell Line:Human embryonic kidney cell line HEK293 cells Concentration:1, 5, 10 μM Incubation Time:24 hours Result:HEK293 cells were almost unaffected.
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体内实验Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells Dosage:2 mg/kg Administration:Intraperitoneally injected; for 3 weeks, except on weekends. Result:Inhibited cancer growth in vivo.
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同义词——
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通路Chromatin/Epigenetic
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靶点Sirtuin
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受体β-Lactamase
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研究领域——
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适应症——
化学信息
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CAS Number1807758-81-1
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分子量285.73
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分子式C15H12ClN3O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 500 mg/mL (1749.90 mM)
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SMILESNc1cccc(Nc2ncc(-c(cc3)ccc3Cl)o2)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Papp-Wallace KM, et al. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086.